High-Speed Analysis of Impurities of Pramipexole Dihydrochloride by Prominence-i

The Kinetex 5 μm core-shell column, in which the applied pressure is equivalent to that using a 5 μm particle column, permits analysis at very high resolution. Therefore, high- resolution, high-sensitivity chromatograms can be obtained even when using a general-purpose LC system.
Here, we introduce an example in which we used the Kinetex 5 μm core-shell column in the Prominence-i integrated high-performance liquid chromatograph, with the aim of speeding up the analysis of a drugrelated substance in accordance with criteria requirements of the European Pharmacopoeia (EP).