Fish is one of the most important food resource that is widely consumed in many parts of the world. However, because of industrial discharges from human activities, fish may have trace levels of toxic elements such as arsenic, cadmium, lead, mercury and nickel which are absorbed from the surrounding waters and the foods they eat. The toxicity of these metals poses a concern to human health through the consumption of fish. Here, Shimadzu ICPMS-2030, a inductively coupled plasma mass spectrometer (ICP-MS) was used to conduct a simultaneous analysis of elements in fish. In addition to being highly sensitive, the ICPMS-2030 uses a helium gas collision system that greatly reduces the spectral interference caused by argon and chlorine.