High Sensitivity Quantitation Method of Dicyandiamide and Melamine in Milk Powders by Liquid Chromatography Tandem Mass Spectrometry

Melamine was found to be used as a protein-rich adulterant first in pet-food in 2007, and then in infant formula in 2008 in China. The outbreak of the melamine scandal that killed many dogs and cats as well as led to death of six infants and illness of many had caused panic in publics and great concerns in food safety worldwide. Melamine was added into raw milk because of its high nitrogen content (66%) and the limitation of the Kjeldahl method for determination of protein level indirectly by measuring the nitrogen content. In fact, in addition to melamine and its analogues (cyanuric acid etc), a number of other nitrogen-rich compounds was reported also to be potentially used as protein-rich adulterants, including amidinourea, biuret, cyromazine, dicyandiamide, triuret and urea. Recently, low levels of dicyandiamide (DCD) residues were found in milk products from New Zealand. Instead of addition directly as an adulterant, the trace DCD found in milk products was explained to be relating to the grass "contaminated by DCD". Dicyandiamide has been used to promote the growth of pastures for cows grazing. We report here an LC/MS/MS method for sensitive detection and quantification of both dicyandiamide (DCD) and melamine in infant milk powder samples.

Content Type:
Paper
Document Number:
PO-CON1459E
Product Type:
Liquid Chromatography, Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
Melamine, Dicyandiamide, Food and Beverages, Food safety (Residues, Contaminants), LCMS-8040, Nexera UHPLC
Language:
English
File Name:
apo114063.pdf
File Size:
175kb

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