Multi-component quantitative analysis of pharmaceuticals and personal care products in the environment by LC-MS/MS with fast polarity switching

The analysis of EPA624 regulated volatile organicscompounds in drinking and waste water is usually doneswith headspace or purge and trap technique using a soscalled 624 phase with 30 m, 0.25 mm, 1.4 μm according tosthe EPA method 624. Reducing analysis time (fast GC) butsmaintaining chromatographic resolution has beenssuccessfully applied using narrow bore columns in varioussfields. In Headspace analysis the transfer of sample fromsthe insert to the column is quite slow as normally small splitsratios are used in favour of sensitivity which has been inscontradiction to fast GC approaches. This paper deals withsfast GC approach in combination with Headspacessampling. Helium and Hydrogen was used as carrier gas.