A new device for direct QuEChERS salts extraction: application to drugs of abuse in blood, urine and oral fluid

Extraction procedures using QuEChERS consist of manually adding salts to the analyzed matrix, previously mixed in a polar solvent (acetonitrile, ACN). This approach is largely employed for pesticides residues but also for multiples classes of drugs.

- In this study, we explored the performance of a QuEChERS extraction based on a new pre-packed kit containing 100 mg of salts (Micro Volume QuEChERS; MVQ) and compared it to a previously validated procedure, routinely used in a clinical lab.

The example of an LC-MS method for the analysis of 44 Drugs Of Abuse (DOA) using this new device is presented.

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Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
QuEChERS, blood, urine, oral fluid, Clinical research, Forensics, Pharmaceutical, Life Science, Forensics, Toxicology, Drug test, LCMS-8060
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