A Novel Wire Desorption ElectroSpray/Glow Discharge Ionization Source for Fast Identification of a Broad Range of Compounds

A novel ambient ionization source, WD-ESI/GDI source, was developed to analyze mixtures containing analytes with different polarities and thermal stabilities in different phases at atmospheric pressure. WD-ESI/GDI had four significant advantages: 1) low thermal capacity - fast heating & cooling; 2) self-cleaning; 3）simple operation for thermal desorption without carrier gas; 4) a universal ion source for analytes with different polarities, state and thermal stability. Figure 1 displays the desorption and ionization processes occurred in WD-ESI/GDI.