Characterization of products formed by forced degradation of Amlodipine Besylate using LC/MS/MS

Amlodipine was degraded under 3 different conditions and degradation products were studied. Structures were predicted using fragmentation pattern.
Initially, chromatographic method was optimized using gradient mode for Amlodipine degradation products. The ESI MS/MS parameters were optimized, both for ionization source and collision energies, for the observed degradation products.
Depending on the degradation type, possible chemical reactions were predicted and supported by fragmentation information from LCMS-8080.
For base degradation, a product of m/z 381 was observed and its structure could be predicted from fragmentation pattern. Similarly, product formed from oxidative degradation showed m/z 407 which could be correlated to Amlodipine structure.

Content Type:
Document Number:
Product Type:
Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
LC/MS/MS, Amlodipine Besylate, Pharmaceutical, Life Science, Drug discovery, LCMS-8080
File Name:
File Size:

Free Download

For Research Use Only. Not for use in diagnostic procedures.

This page may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country.

Top of This Page