Characterization of products formed by forced degradation of Amlodipine Besylate using LC/MS/MS

Amlodipine was degraded under 3 different conditions and degradation products were studied. Structures were predicted using fragmentation pattern.
Initially, chromatographic method was optimized using gradient mode for Amlodipine degradation products. The ESI MS/MS parameters were optimized, both for ionization source and collision energies, for the observed degradation products.
Depending on the degradation type, possible chemical reactions were predicted and supported by fragmentation information from LCMS-8080.
For base degradation, a product of m/z 381 was observed and its structure could be predicted from fragmentation pattern. Similarly, product formed from oxidative degradation showed m/z 407 which could be correlated to Amlodipine structure.

Content Type:
Paper
Document Number:
PO-CON1315E
Product Type:
Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
LC/MS/MS, Amlodipine Besylate, Pharmaceutical, Life Science, Drug discovery, LCMS-8080
Language:
English
File Name:
ipo113020.pdf
File Size:
224kb

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