Multiresidue pesticide analysis from dried chili powder using LC/MS/MS

Pesticide residues in foodstuffs can cause serious health problems when consumed. LC/MS/MS methods have been increasingly employed in sensitive quantification of pesticide residues in foods and agriculture products.
However, matrix effect is a phenomenon seen in Electro Spray Ionization (ESI) LC/MS/MS analysis that impacts the data quality of the pesticide analysis, especially for complex matrix like spice/herb.
Chili powder is one such complex matrix that can exhibit matrix effect (either ion suppression or enhancement). A calibration curve based on matrix matched standards can demonstrate true sensitivity of analyte in presence of matrix.