Identification of novel pyrimidine ring cleavage metabolites of Buspirone via Spectral Similarity correlation score

Buspirone is an anxiolytic psychoactive drug of the azapirone chemical class, and is primarily used to treat generalized anxiety disorder (GAD). Buspirone is a common model compound for xenobiotic metabolism. Here we describe the application of a Spectral Similarity Correlation methodology (‘S Score’) to the analysis of data generated from a human microsomal incubation of Buspirone. Non-targeted data-dependent MSMS data was collected from a human microsomal incubate using a Shimadzu LCMS IT-TOF system. The 'S scores’were derived from the correlation of fragment ion and neutral loss species of unknown chromatographic peaks to those of Buspirone. This approach was unbiased and success was not influenced any user interaction.

Content Type:
Paper
Document Number:
ASMS2012_WP23-472
Product Type:
Liquid Chromatography, Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
Buspirone, Pharmaceutical, Life Science, DMPK, ADME, Safety testing, LCMS-IT-TOF
Language:
English
File Name:
jpo112144.pdf
File Size:
73kb

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