Effects of Polarity Switching in High Speed LCMS Analysis

The introduction of high-speed analysis into the laboratory brings rapid improvements in efficiencies for businesses conducting research and development, testing and inspection, etc. As this liberates chemists from time consuming analytical operations, it opens up the possibility of using that time on other business-related activities.
In the case of LC, the advent of UHPLC (Ultra-High-Performance LC) has produced a positive effect on throughput which has fueled widespread proliferation of this technique. The same cannot be said of LCMS, in which high-speed analysis is not yet the norm. That is because several hurdles must be overcome to achieve higher speeds with LCMS. One key problem is that in multi-component analysis, it is frequently necessary to detect ions in both positive and negative modes simultaneously. However, the slow MS transition time between positive and negative ion modes (polarity switching) is a hurdle that still exists at this time. This problem effectively limits the use of MS as a detector to many UHPLC methods.

Content Type:
Application
Document Number:
C146-E176
Product Type:
Liquid Chromatography, Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
Polarity Switching, Pesticides, Food and Beverages, Food safety (Residues, Contaminants), LCMS-8030
Language:
English
File Name:
jpo113014.pdf
File Size:
1,384kb

Free Download

For Research Use Only. Not for use in diagnostic procedures.

This page may contain references to products that are not available in your country. Please contact us to check the availability of these products in your country.

Top of This Page