LC/MS/MS has become an essential tool for the routine analysis in the field of forensic toxicology. It allows you to conduct the simultaneous analysis of multiple compounds in a single run which makes it possible to carry out a fast and high throughput analysis. In this study, we report a newly developed rapid screening method covers common 161 forensic drugs in Japan using ultra-high speed triple quadrupole mass spectrometry. This method also incorporates with information of calibration curve for all 161 using two internal standards. The use of synchronized survey scanning (MRM triggered product ion scanning) output both quantitative and qualitative results in a single run.