LC-MS Bioanalysis of Antibody Drugs Using Fab-Selective Proteolysis nSMOL - Part 5
- Instrument comparison of precision and accuracy -

nSMOL is Shimadzu's completely new and breakthrough technology that enables selective proteolysis of the Fab region of monoclonal antibodies. The nSMOL Antibody BA Kit comprises the reagents and protocols necessary for bioanalyses using nSMOL proteolysis. This article introduces how nSMOL proteolysis is optimized for the Shimadzu LCMS-8050 and LCMS-8060 compared with vender product hybrid LC-MS system.

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Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
LC-MS Bioanalysis, Antibody drug, Fab-selective proteolysis, Bevacizumab, Pharmacokinetics, Therapeutic drug monitoring, Pharmaceutical, Life Science, Manufacturing, QA/QC, nSMOL, LCMS-8060, LCMS-8050
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