MRM spectrum mode and Library Searching for Enhanced Reporting Confidence in Forensic Toxicology

The majority of clinical decisions are based on laboratory test results. For many laboratories. Triple quadrupole MRM methods are used to deliver highly sensitive, selective and robust for precise quantification and identification verification. To help transition towards a more effective data review and higher confidence in reporting results. We have been rethinking the capability of MRM in compound identification and verification. In this workflow, 6-10 fragment ion transitions were monitored for each target compound as opposed to a conventional approach using 2-3 fragment ions. By acquiring a high number of fragment ion transitions, each target compound had a corresponding fragmentation spectra which could be used in routine library searching and compound verification using reference library match to clinical and forensic toxicology.

Content Type:
Paper
Document Number:
PO-CON1808E
Product Type:
Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Keywords:
MRM spectrum mode, Library Searching, fragment ion, Clinical research, Forensics, Forensics, Toxicology, Drug test, LCMS-8060, Nexera X2
Language:
English
File Name:
jpo118036.pdf
File Size:
723kb

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For Research Use Only. Not for use in diagnostic procedures.

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