Establishment of a Method for Direct Analysis of the Mouse Brain Metabolome Using the DPiMS™-8060

In the analysis of endogenous metabolites (metabolome analysis), it is difficult to perfectly remove biases caused by pretreatment and sampling. Therefore, in order to accurately grasp the changes in the metabolome of a biospecimen, the establishment of a method for direct analysis of the metabolome is indispensable. By using the DPiMS-8060, direct and rapid analysis of metabolites in brain samples was possible without any pretreatment. This article introduces a method for analyzing brain metabolites using a PESI tandem mass spectrometer.

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Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
PESI, DPiMS, Life science, Metabolomics, Metabolome, Metabolite, Direct analysis, Rapid analysis, Mouse, Brain, Amino acid, Lipid, Sugar, Multivariate analysis, Clinical research, Forensics, Pharmaceutical, Life Science, DMPK, ADME, Safety testing, DPiMS-8060
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