Rapid analysis of drugs in plasma using probe electrospray ionization mass spectrometry

Drugs with low effective blood concentration such as immunosuppressant have large pharmacokinetic variability and therapeutic drug monitoring is required to minimize toxic side effects. Therefore, measuring drug concentration quickly and accurately is important for clinicians to carry out timely and appropriate treatment for patients. However, complicated pretreatment is required for measurement of drugs as complex metabolite components in the blood influence on measurement. Therefore, it is difficult to obtain the analysis result quickly.
In this study, PESI/MS/MS system is enabled rapid and simple quantitative analysis of Everolimus and Abiraterone in commercial plasma components by simple pretreatment with deproteinization only.