Evaluation of micro volume sample preparation technology newly designed for forensic toxicology with High Resolution Accurate Mass Spectrometry

In recent years, new synthetic drugs have appeared in the illicit market. These compounds include various analogs and newly emerged compounds with different chemical structures. One of the major points of concern is the substantial ineffectiveness of current toxicological sample pretreatment and screening methods to identify the compounds in biological samples. The recent increase in the sales and abuse of substituted drugs highlighted the need for fast and reliable identification of such compounds with a simple sample preparation technology everybody can easily and smoothly implement. This work describes the identification workflow of pre-spiked drugs treated with micro-volume QuEChERS extraction protocol using high resolution accurate mass spectrometry.

Content Type:
Paper
Document Number:
ASMS2019-MP220
Product Type:
Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry, quadrupole time of flight(Q-TOF) mass spectrometer
Keywords:
toxicological sample,QuEChERS, Etizolam, triazolam, Clinical research, Forensics, Pharmaceutical, Life Science, DMPK, ADME, Safety testing, Development (Formulation, Scale-up, Method development), Toxicology, Drug test, Nexera X2, LCMS-9030
Language:
English
File Name:
jpo119105.pdf
File Size:
939kb

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