Determination of Molecular Mass and Quantification of Oligonucleotide Therapeutics Using Quadrupole Time-of-Flight Mass Spectrometer LCMS™-9030

Oligonucleotide therapeutics are synthetic oligonucleotides that exert their medicinal effects by binding to target genes or proteins that cause various diseases. They are attracting attention as a third class of drugs after small molecule drugs and antibody drugs.
Here is an example of confirmation of molecular weight and quantification using the Q-TOF mass spectrometer LCMS-9030.