Simultaneous Analysis of Remdesivir and Metabolites in Human Plasma
Remdesivir (Brand Name: Veklury) is a prodrug developed by Gilead Science Inc. (The U.S.) for the treatment of Ebola hemorrhagic fever. It shows antiviral activity against single-stranded RNA virus and is known to be metabolized in vivo to activated GS -441524.
In this report, we have constructed an analytical system that enables simultaneous measurement of Remdesivir and its metabolites using LC-MS/MS, which is a highly selective analytical method.
- Content Type:
- Application
- Document Number:
- C218
- Product Type:
- Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
- Keywords:
- Prodrug, Veklury, Remdesivir, GS -441524, Alsachim stable isotope labeling reagent, deproteinization, Pharmaceutical, Life Science, LCMS-8060
- Language:
- English
- File Name:
- jpo120038.pdf
- File Size:
- 226kb