Retention time prediction for 653 pesticides on a biphenyl liquid chromatography stationary phase using machine learning
Suspect screening large numbers of analytes by a single LC-MS/MS method has become more widespread in recent years with new advances in high speed data-dependent (DDA) or data-independent (DIA) acquisition methods. The process of molecular identification can however be challenging when it is not possible to measure an authentic standard. Retention time verification (or prediction) is a critical tool in suspect screening. The ability to predict retention times on C18has recently been demonstrated using machine learning tools, but models have not been explored for other reversed-phase media which may offer alternative selectivity to enhance component identification. In this work, the prediction of retention times for a diverse chemical space is considered using artificial neural networks for a biphenyl stationary phase.
- Content Type:
- Paper
- Document Number:
- ASMS2019-ThP345
- Product Type:
- Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry, triple quadrupole LC-MS/MS
- Keywords:
- molecular identification, biphenyl stationary phase, advances in high speed data-dependent(DDA), advances in high speed data-independent (DIA), artificial neural networks, pesticides, Food and Beverages, Agriculture, Food safety (Residues, Contaminants), LCMS-8060
- Language:
- English
- File Name:
- uko119101.pdf
- File Size:
- 432kb