MS Imaging of Rat Liver Tissue Sections Using MALDI-7090

When discussing the disease progression, we need to know what molecules are changing where in the tissue. Analysis using LC-MS/GC-MS is effective in determining quantitative changes of molecules, but due to the nature of the method, information about where target molecules are located in the tissue section is lost.
As a solution to this problem, in this article, we introduce an example of analyzing the relationship between pathological findings and molecular distribution by combining the data obtained by LC-MS/GC-MS with the conventional tissue chemical staining method and MS imaging with the MALDI-7090, which offers high resolution.