Multimodal Imaging of Ischaemic Rat Brain, 1-3 months on: A MALDI MS insight into long term molecular expression

Inflammatory responses are observed in the brain mostly acutely after stroke. This neuroinflammation can be seen with various imaging techniques: PET scans, MR scans, Immunohistochemistry (IHC) and MALDI-MS imaging. In this study we have taken a further look at molecular expression/distribution between one and three months post-stroke. In this case the proteins targeted in PET and IHC did not highlight any significant differences between healthy brain tissue and regions of the brain damaged by stroke. As such, our aim in these analyses was to look at a broader range of molecules using a data mining approach to determine whether MALDI would elucidate any additional information.

Content Type:
Paper
Document Number:
PO-CON1561E
Product Type:
Mass Spectrometry, Life Science Lab Instruments, MALDI-TOF Mass Spectrometry
Keywords:
stroke, neuroinflammation, brain tissue, Clinical research, Forensics, Clinical research, MALDI-MS Imaging, MALDI-7090
Language:
English
File Name:
uko315073.pdf
File Size:
1,953kb

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