Observation and Measurement of Cells with SPM (II): Measurement of Cell Hardness

The hardness of HeLa cells and iPS cells in the live condition was measured with SPM, clarifying the fact that HeLa cells have uniform hardness, whereas iPS cells are characterized by higher hardness in areas of intercellular adhesion. It is considered possible that this hard intercellular adhesion has some kind of influence on maintenance of the undifferentiated state and the pluripotency of iPS cells.

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Surface Analysis
SPM, scanning probe microscope, iPS cell, HeLa cell, intercellular adhesion, regenerative medicine, force curve mapping, hardness measurement, ZX image, amount of cell deformation, Pharmaceutical, Life Science
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