Join our Program to find Innovative Technologies in Mass Spec and Imaging at Metabolomics 2014
|Date:||June 23 to 26, 2014|
The goal of Shimadzu in metabolomics community is to provide innotative technologies. Towards this, we announced that we will participate in the 10th International Conference of the Metabolomics Society in Tsuruoka Japan.
Founded on the basis of "Contributing to Society through Science", Shimadzu is honor to introduce our innovative technologies of mass spectrometry and mass imaging to metabolomics society.
We look forward to your participation. Thank you.
Tuesday, June 24th, 12:30h - 13:30h Marica Hall
Masaru Yoshida, M.D., Ph.D.
Division of Metabolomics Research & Gastroenterology, Kobe University
Graduate School of Medicine
Metabolome analysis for discovering biomarkers of cancers.
Improvements in analytical technologies have made it possible to rapidly determine the concentrations of thousands of metabolites in any biological sample, which has resulted in metabolome analysis being applied to various types of research, such as clinical, cell biology, and plant/food science studies. The metabolome represents all of the end products and by-products of the numerous complex metabolic pathways operating in a biological system. Thus, metabolome analysis allows one to survey the global changes in an organism's metabolic profile and gain a holistic understanding of the changes that occur in organisms during various biological processes, e.g., during disease development. In clinical metabolomic studies, there is a strong possibility that differences in the metabolic profiles of human specimens reflect disease-specific states. Recently, metabolome analysis of biofluids, e.g., blood, urine, or saliva, has been increasingly used for biomarker discovery and disease diagnosis. Mass spectrometry-based techniques have been extensively used for metabolome analysis because they exhibit high selectivity and sensitivity during the identification and quantification of metabolites. Here, we show metabolome analysis using gas chromatography-mass spectrometry. Furthermore, we discuss metabolome analysis-based disease diagnosis.
|Development and evaluation of a comprehensive monitoring method for eicosanoid species using a high-speed LC/MS with continuous ionization polarity switching||Masaki Yamada1, 2, Yoshihiro Kita1, Takahiro Kohira3, Suzumi M. Tokuoka1, Takao Shimizu1, 4
2. Shimadzu Corporation, Kyoto, Japan3. Japanese Red Cross Society, Tokyo, Japan4. National Center for Global Health and Medicine, Tokyo, Japan
1. Department of Lipidomics, Faculty of Medicine, TheUniversity of Tokyo
|Simultaneous measurement of metabolites in MRM mode by a triple quadrupole LC/MS/MS using pentafluorophenylpropyl column||
Tsuyoshi Nakanishi1, Takako Hishiki2, 3, Makoto Suemtsu2, 3
2 .Department of Biochemistry, School of Medicine, Keio University, Tokyo, Japan3. Japan Science and Technology Agency, Exploratory Research for Advanced Technology, Suematsu Gas Biology Project, Tokyo, Japan
1. Analytical Instruments Div., Shimadzu Co. Ltd., Kyoto, Japan
|Accurate Determination of Metabolites in Serum Using MRM Mode in a Triple Quadrupole GC/MS/MS and MRM Metabolites Database||Shuichi Kawana,
|Pharmacokinetics of Chlorpromazine and its Metabolomic analysis using Imaging Mass Microscope, iMScope||Koretsugu Ogata,
|Compound identification technique for conjugated unknown metabolites using accurate mass with MSn analysis.||
Tairo Ogura1, 2, Akihiro Tai3, Takeshi Bamba1, Eiichiro Fukusaki1
1. Graduate School of Engineering, Osaka University, Osaka, Japan
2. Shimadzu corporation, Kyoto, Japan
3. Prefectural University of Hiroshima, Hiroshima, Japan
|Integrated targeted metabolome and proteome analysis for dissecting yeast metabolic system||
Fumio Matsuda1, Syunsuke Nishino1, Tairo Ogura2, Nobuyuki Okahashi1, Atsumi Tomita1, Ichiro Hirano2, and Hiroshi Shimizu1
1. Graduate School of Information Science and Technology, Osaka University,
2. Shimadzu corporation, Kyoto, Japan
GCMS-TQ8040 is the first triple quadrupole with Smart Productivity for high efficiency sample throughput, Smart Operation for quick and easy method development, and Smart Performance for low detection limits and Scan/MRM.
Imaging Mass Microscope
The instrument is a combination of an optical microscope which allows the observation of high-resolution morphological images, with a mass spectrometer which identifies and visualizes the distribution of specific molecules.
The LCMS-8050 is capable of simultaneously obtaining both qualitative and quantitative information in a single analysis. Acquisition occurs so rapidly that MS/MS scans and MRM measurements can be performed concurrently while maintaining quantitative accuracy.