Shimadzu's New i-Series Plus Integrated High-Performance Liquid Chromatograph Significantly Improves Analytical Productivity with Automated Pretreatment Operations

Shimadzu Corporation has released the i-Series Plus integrated high-performance liquid chromatograph. With i-Series Plus, pretreatment operations, such as the processes to dilute samples and add reagents, have been automated, resulting in less mistakes and measurement errors and ensuring highly reproducible and reliable data in the analysis of pharmaceuticals and foods. i-Series Plus also has functions that satisfy the data integrity required in the pharmaceutical industry.

Since the release of i-Series systems in 2014, they have received widespread acceptable by customers for their excellent performance and user-friendliness, including a stable baseline achieved by detectors that are resistant to room temperature variation, high reproducibility in micro quantity injection of 1 μL or smaller, and operations using a touch panel. As a result, 10,000 units have been sold around the world. They have been used for research and development activities, specification tests, and quality control operations in a wide range of industries, including the pharmaceutical, chemical, and food industries, and at numerous government agencies and universities. i-Series Plus expands the product line and improves performance and user-friendliness. The new system is equipped with a function to automate sample pretreatment, which serves to minimize operators' mistakes and measurement errors, improve the separation of the target components, and enhance sensitivity.

 
  • Character "i" of i-Series stands for "Innovative" for further advancement, "Intuitive" for futuristic features, and "Intelligent." It was named with an aim to make this new-generation LC system an industry standard.
 
  • The i-Series product line is shown below.
Prominence-i

An integrated high-performance liquid chromatograph that provides excellent performance and user friendliness. It provides highly-stable baselines by incorporating a double temperature control function in the detector that is resistant to room temperature variations, and high reproducibility in micro quantity injections of 1 μL or less. It also has a main unit with a touch panel and a part replacement navigation function. It is highly compatible with other instruments. For example, it can obtain data that is compatible with data obtained using a different manufacturer's LC unit. Released in 2014.

Nexera-i

In addition to the basic performance described above, this UHPLC system has pressure resistance of 66 MPa to support ultra-high-speed analysis using a core shell column. Released in 2014.

Prominence-i LT

A wider range of detectors can be used on this model to handle various types of samples. Released in 2015.

Nexera-i MT

Simplifies the process of migrating methods between an ultra high performance liquid chromatograph (UHPLC) and high-performance liquid chromatograph (HPLC). Released in 2016.

Features

1. Automated Sample Pretreatment Operations

The system has pretreatment functions to adjust the samples before starting analysis, including processes to dilute the target component contained in the sample to be measured and add a certain amount of a reaction reagent in order to detect the target component with high sensitivity. The system can automatically dilute samples up to 100 times. Automatically adding a reagent allows a wider range of components to be directly analyzed. For example, amino acid components in foods can be analyzed in a short time with high sensitivity.

2. Supports Data Integrity for Pharmaceuticals

There have been a number of cases that do not satisfy the requirements for data integrity specified by regulatory agencies, making pharmaceutical manufacturers concerned about this issue. Strict observance of the requirements for analytical data management (Attributable, Legible, Contemporaneous, Original, Accurate) is demanded even more. Analytical instruments are required to have a function to limit orphan data (measurement results that can be acquired or actions that can be performed without leaving records on the instrument). The i-Series Plus has a mode to inhibit orphan data. Both the instrument and software support data integrity.

i-Series Plus

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i-Series Plus LC Systems

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