Shim-pack Bio Diol : Size Exclusion Chromatography Columns

With different pore sizes, Shim-pack Bio Diol LC columns are effective for analysis of aggregates and fragments of mAb, oligonucleotides and carbohydrates.

Shim-pack Bio Diol Diol-60 Diol-120 Diol-200 Diol-300
Particle Silica
Ligand Dihydroxypropyl(Diol)
Particle Size 3 μm,5 μm 2 μm,3 μm,5 μm
Pore Size 6 nm 12 nm 20 nm 30 nm
pH Range 5.0 - 7.5
Weight Range
below 10,000 1,000 - 100,000 5,000 - 300,000 20,000 - 1,000,000

Shim-pack Bio IEX : Ion Exchange Chromatography Columns

Shim-pack Bio IEX Columns are available in Q (quaternary ammonium) and SP (sulfopropyl) chemistries and are based on porous (Q and SP columns) and non-porous (Q-NP and SP-NP columns) hydrophilic polymers with low nonspecific adsorption. The porous particles offer excellent binding capacity with exceptionally high efficiency and the non-porous particles offer high efficiency and exceptional resolution.

Analysis of Synthesized Oligonucleotide (Single Strand DNA) using Shim-pack BIO IEX Q-NP

Shim-pack Bio IEX Q-NP SP-NP Q SP
Particle hydrophilic non-porous polymer hydrophilic non-porous polymer
Particle Size 3 μm,5 μm 5 μm
Ligand -CH2N+(CH3)3 -(CH2)3SO3- -CH2N+(CH3)3 -(CH2)3SO3-
pH Range 2 - 12

Shim-pack Bio HIC:Hydrophobic Interaction Chromatography

Shim-pack Bio HIC Column is a hydrophobic interaction chromatography (HIC) column packed with butyl bonded hydrophilic nonporous polymer particles (4μm). HIC is suitable for the separation of anlaytes with slightly different hydrophobicity, such as antibody-drug conjugate (ADC) with different drug-antibody ratios (DAR). Shim-pack Bio HIC can be used for the analysis of DAR of ADC with relatively low pressure and high resolution.


Order Information

  Shim-pack Bio HIC
Particle Size 4 µm
4.6 x 100mm 227-31174-01


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