i-series Plus - Options

High-Performance Liquid Chromatograph

Analytical Columns that Support Method Development

The scalability of columns used in method scouting is important for method development. Shim-pack GIS/GIST/GISS series columns are available in sizes from 5 mm, suitable for HPLC analysis, to 2 mm, suitable for UHPLC analysis, allowing smooth transfer of analytical methods obtained by UHPLC method scouting for HPLC analysis. The series is also available with a wide range of modified groups, which are powerful tools in method development.

Shim-pack GIS Series

Genuine Ideal Symphony Ideal Generic HPLC Columns

Highly regarded throughout the world, Shim-pack GIS series HPLC columns are packed with high-purity silica gel. A highly uniform pore size ensures a good mobile phase flow path and excellent low pressure performance. Not only can this substantially reduce mobile phase solvent costs, but system load can be reduced.
The silica gel surface is uniform and chemical modifications are stable, providing excellent reproducibility.

Shim-pack GIST Series

Genuine Ideal Symphony Tenacity Highly Stable, Highly Durable

Shim-pack GIST series columns are packed with high-purity porous spherical silica. Their increased inertness not only improves peak shapes, but also increases durability. The series columns also have a large working pH range (1 to 10), and are designed for ease-of-use during analysis of a wide variety of compounds.
Reproducibility between production lots is also excellent, with the series columns recommended not only for quality control and research and development, but also for people just starting out in analysis.
This series is available in a variety of pore sizes, which makes it easy to migrate methods between conventional and ultra-high-speed analysis.

Shim-pack GISS Series

Genuine Ideal Symphony Speed Robust Inertness, High-Speed Analysis

Shim-pack GISS series columns are designed with the robust inertness and wide working pH range of the GIST series, while also delivering rapid elution times and sharp peaks. Packing surface area, pore size, and chemical modification have been optimized for excellent peak shapes, making these columns ideal for high-sensitivity LC/MS/MS analysis.
This series also includes the 1.9 mm and 3 mm HP series for UHPLC analyses.

Nexera-i MT Method Transfer System

Enables Both HPLC and UHPLC Analysis

The Nexera-i MT is a new addition to the i-Series Plus lineup. It enables both conventional analysis via its high compatibility with existing LC systems and rapid analysis via high-speed methods. In pharmaceutical development, a single integrated system allows process synthesis screening analysis for synthetic substances in the UHPLC flow line, and impurity content identification in the HPLC flow line.

Analysis results from LC systems in the same laboratory may differ, even with the same method, due to differences in the volumes of these systems. The Nexera-i MT demonstrates outstanding reproducibility between various LC systems with different system volumes, simplifying method transfer between instruments.

Further more, with the Nexera-i MT the process of migrating from UHPLC to HPLC or from HPLC to UHPLC can be accomplished using a single system.

The Nexera-i MT is based on the same user-friendly i-Series Plus, but maximizes performance and reliability for migrating and transferring customer methods.

Dual Flow Lines Simplify the Process of Migrating Methods

A single integrated system allows analyses in two flow lines with UHPLC and HPLC delay volumes. In addition to simplifying the transfer of analytical methods for customers using HPLC, it can also streamline the process of converting customers' analytical methods from HPLC to higher-speed UHPLC.

Supports Method Compatibility Compliant with the United States Pharmacopeia

General Chapter <621> Chromatography in the United States Pharmacopeia specifies allowable ranges for changes to analytical parameters, so that revalidation is not necessary as long as the setting values remain within those allowable ranges. Nexera-i MT includes dual flow lines for HPLC and UHPLC analysis. With two system volumes, it can support both existing analytical methods and UHPLC methods.

ACTO Function Achieves Higher Reproducibility

The newly developed Analytical Condition Transfer and Optimization (ACTO) function incorporated in LabSolutions allows users to transfer injection timings matched to differences in system volumes between instruments, without editing the concentration gradient programs in existing methods.

More Optimal Method Transfer with a Simple Operation

Reproducing analysis results is difficult even when the same columns and the same mobile phase conditions are used, because the gradient analysis start times differ due to differences in internal volumes between LC systems. With the ACTO function, differences in internal volume can be fine-tuned to heighten data reproducibility between different systems and streamline method transfer.

Achieves Seamless Method Transfer Process


Transfer Methods with a Single Button Operation—ACTO Function

The ACTO function also includes functionality for transferring HPLC methods to UHPLC methods. Just by loading method files prepared on an existing system and entering information about the columns used, the optimized methods will be presented for fast analysis. By selecting one of the flow lines, the function can also transfer methods from UHPLC to HPLC.

The Nexera-i MT has two flow lines matched to the UHPLC and HPLC delay volumes. In addition to simplifying method transfer for customers using HPLC, this single integrated system also streamlines reviewing procedures for increasing the speed of customers' methods using UHPLC.

Designed for User-Friendly Operability

—Core Technologies That Provide a Solid Foundation for Analysis
Core Technologies That Provide a Solid Foundation for Analysis

Utilizing Method Scouting for Method Development

i-Series Plus is now compatible with method scouting systems.* Attaching a flow line switching valve allows up to six columns and four mobile phases to be switched automatically for analysis and to obtain optimum conditions for separation. Many i-Series Plus systems are used in manufacturing departments and other areas due to their simplicity, and performing method development with the same system improves the efficiency of method migration operations.
* Not including Nexera-i MT

Mobile Phase and Column Database

Preregistering the mobile phases and columns to be used can make it easy to specify method settings. In addition, the database includes a sort function that makes it easy to find the desired mobile phase or column even if a large number have been registered.

Evaluating Mobile Phase and Column Conditions

The estimated analysis end time is displayed based on the specified method and conditions being evaluated. Therefore, condition settings can be specified based on operating plans, such as by adjusting the number of samples or number of injections (both with a maximum of 10).

Evaluating Gradient Conditions

An extensive range of gradient patterns, such as isocratic, multilinear, or stepwise, can be specified. Concentration conditions for specific locations can be easily changed and up to 100 gradient patterns can be evaluated.

Automatic Batch Settings

Batch files are created automatically based on the condition settings being evaluated.
The created batch file can be edited before analysis starts, or analysis the analysis can be automatically started without editing the file. Processes performed after analysis can also be automated by specifying column rinsing and shutdown settings.

Quickly and Immediately Check Results When Analysis Is Finished

Data Browser can be used to display multiple chromatograms by simply dragging and dropping multiple sets of acquired data to the window. This enables quick comparison of the analytical results for more efficient decision-making.
Using the multi-data report function improves the visibility of data when considering a large number of results. It can be used to compare a large number of conditions based on the same criteria, such as resolution and number of peaks, and then to assign values accordingly to determine the optimal conditions.
Results for all the conditions considered can be automatically output as an Excel file, which provides powerful support for medium and long-term data management.

Drivers

Labsolutions Series

Software Option

Related information