Benefits of an MS Detector
With their High Sensitivity, High Detection Selectivity, and High Qualitative Capability, MS Detectors Bring Improved Productivity to HPLC Analysis
In the pharmaceuticals, food products, and environmental fields, HPLC is widely utilized due to the prevalence of thermally unstable components and refractory contaminants. However sufficient sensitivity cannot be always attained with standard UV detection alone. There has been an increase in occasions on which sophisticated separation conditions must be investigated, such as when analyzing trace components in complex matrices. Furthermore, qualitative and quantitative faults are sometimes overlooked due to the impact of impurities, resulting in insufficient reliability. It is with these requirements that MS detectors, which measure signals for each component mass, fully demonstrate their worth.
High Sensitivity Measurements of Compounds with Almost no UV Absorption
As an example, macrolide antibiotics have no conjugated double bonds, and have almost no UV absorption. As a result, high sensitivity analysis cannot be anticipated without modification. With LC-MS, high sensitivity analysis is possible, even in the unmodified state, by utilizing selected ion monitoring (SIM) mode, in which protonated ions (M+H)+ are used as the monitor ions.
Selective Detection by Component in a Multi-Component Simultaneous Analysis
Carbamate pesticides are thermally unstable, and are suited to analysis with HPLC or LC-MS systems. With LC-MS, a high-sensitivity chromatogram can be obtained based on the mass information, even if the components are not separated completely. As a result, LC-MS demonstrates its worth in the simultaneous analysis of such samples. (Not only are multiple target components selectively detected, but the impact of contaminant components is easily eliminated.)
Using LC-MS, even multi-component simultaneous analysis can be performed without spending time and effort on investigating separation conditions.
|1) Carbendazim||2) Asulam||3) Oxamyl||4) Methomyl|
|5) Thiophanate-methyl||6) Thiodicarb||7) Carbaryl||8) XMC|
|9) Thiuram||10) Isoprocarb||11) Benomyl||12) Dimepiperate|
|13) Benfuracarb||14) Carbofuran|