High Resolution Scanning Probe Microscope

In Liquid

Molecular Structure of Proteins 1)

Egg-white lysozyme was observed in a saturated aqueous solution. Protein molecules (the circles in the figure at left) can be observed within the surface unit cell (the square in the figure at right)..

Mixed Crystalline Structures

This illustrates the observation of epitaxially-grown Na2MgCl4 crystals on a single NaCl crystal surface in a mixed solution.
Because the crystalline structure can be observed, this technique can be used to identify the structure of mixed samples.

Atomic Structure of a Calcite Cleavage Plane 2)

This is an atomic-resolution observation of surface structure in a liquid medium. Defects in the calcite surface are evident in the figure at left.

Cited References

  1. K. Nagashima, M. Abe, S. Morita, N. Oyabu, K. Kobayashi, H. Yamada, R. Murai, H. Adachi, K. Takano, H. Matsumura, S. Murakami, T. Inoue, Y. Mori, M. Ohta, R. Kokawa, Molecular resolution investigation of tetragonal lysozyme(110) face in liquid by FM-AFM, Journal of Vacuum Science and Technology B 28 (2010) C4C11-C4C14
  2. Sebastian Rode, Noriaki Oyabu, Kei Kobayashi, Hirofumi Yamada, and Angelika Kuhnle, True Atomic-Resolution Imaging of (1014) Calcite in Aqueous Solution by Frequency Modulation Atomic Force Microscopy, Langmuir, 2009, 25 (5), pp 2850–2853

* All data on this page was obtained using the petri dish type solution cell (option).

For Research Use Only. Not for use in diagnostic procedures.

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