Shimadzu Review Vol.74[1・2](2017)
Healthcare

SPECIALLY COLLECTED PAPERS

Automation and Liquid Chromatography-Tandem Mass Spectrometry in Therapeutic Drug Monitoring

by YMikaël Levi1

Shimadzu Review 74[1・2] (2017.6)

Abstract

Therapeutic drug monitoring has become a pivotal tool for clinicians to individualize therapy, to check observance and maximize response while lowering side effects. Highly accurate and high-throughput analytical technologies are necessary. Liquid chromatography-tandem mass spectrometry has become a major tool to achieve these goals because of its unique capabilities. To fully take its place in clinical laboratories, LC-MS/MS need to adapt to clinical laboratory needs. For this, automation solutions now exist. A general presentation of LC-MS/MS and its advantages over other analytical technologies are presented as well as practical examples of automation solution.

Keywords: Therapeutic drug monitoring, Liquid chromatography-tandem mass spectrometry, Immunosuppressants, Anticonvulsants, Automation


1MS Business Unit, Life Science Business Department, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan

*The information contained in Shimadzu Review has not been modified since the original publication date. Please be aware that in some cases, products mentioned within the articles are no longer available.