Shimadzu Review Vol.74 [1・2] (2017) - Healthcare

SPECIALLY COLLECTED PAPERS

Automation and Liquid Chromatography-Tandem Mass Spectrometry in Therapeutic Drug Monitoring

by YMikaël Levi11
(Received June 26, 2017)

Abstract

Therapeutic drug monitoring has become a pivotal tool for clinicians to individualize therapy, to check observance and maximize response while lowering side effects. Highly accurate and high-throughput analytical technologies are necessary. Liquid chromatography-tandem mass spectrometry has become a major tool to achieve these goals because of its unique capabilities. To fully take its place in clinical laboratories, LC-MS/MS need to adapt to clinical laboratory needs. For this, automation solutions now exist. A general presentation of LC-MS/MS and its advantages over other analytical technologies are presented as well as practical examples of automation solution.

Keywords: Therapeutic drug monitoring, Liquid chromatography-tandem mass spectrometry, Immunosuppressants, Anticonvulsants, Automation

1MS Business Unit, Life Science Business Department, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan

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