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Development of Solid-State Microchip UV Laser for Mass Spectroscopy
by Rakesh Bhandari, Ph.D.1, Tomoyuki Hiroki1, Shingo Uno1, Naoya Ishigaki1, Jiro Saikawa, Ph.D.1, Koji Tojo1, and Yasuhiro Yamakage1
(Received December 11, 2017)
Traditionally, nitrogen gas lasers have been used in Matrix Assisted Laser Desorption/Ionization (MALDI) mass spectroscopy systems. Recently, solid-state lasers have begun to be used, but they have the drawbacks of long pulse width, large size, and high cost.
We have developed a very compact, solid-state microchip UV laser that has a sub-nanosecond pulse width. It uses a patented technique to pump a monolithic laser cavity with a free-space beam to reduce the size and cost.
The 1064 nm fundamental wave is converted to the third-harmonic 355 nm UV using sum-frequency generation. An output of > 30 µJ pulse energy and a 600 ps pulse width with a repetition rate of 1 to 50 Hz is obtained from a palm-top size laser.
This newly developed laser enables high-resolution and cost effective desktop MALDI mass spectroscopy equipment to be achieved. It has the potential to revolutionize the way this equipment is used in hospitals, laboratories, and even space missions.
Keywords: Microchip laser, UV laser, Third-harmonic generation, Mass spectroscopy, MALDI
1Sensor Device Business Unit, Device Department, Shimadzu Corporation, Kanagawa, Japan
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