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Development of Hydrogels Based on the Amphiphilic Copolymers
Poly (Sarcosine) and Poly (L-Lactic Acid)
by Hayato Matsui, Ph.D.1 and Junko Enomoto, Ph.D.1
(Received December 25, 2018)
In the field of regenerative medicine, which has been attracting attention recently, there is demand for techniques such as hydrogel scaffolds to enable the creation of highly functional and safe cell spheroids. Here we report on a novel class of hydrogels based on biodegradable amphiphilic polymers that consist of hydrophobic poly (L-lactic acid) and hydrophilic poly (sarcosine) (PSar-PLLA). The latter is hydrophilic, biocompatible, biodegradable, and has promise as a new material to replace polyethylene glycol. Poly (L-lactic acid), on the other hand, is hydrophobic, biocompatible, biodegradable, and is currently used as a scaffold in bone repair. The hydrogels prepared from PSar-PLLA show promise as a new class of three-dimensional cell culturing tool. In this article, we introduce a method of preparing PSar-PLLA hydrogels, their physical and chemical characterization using viscoelastic and differential scanning calorimetry analysis, and also introduce the cultivation of actual threedimensional cell cultures using PSar-PLLA hydrogels.
Keywords: Biodegradable amphiphilic polymer, PSar-PLLA, Hydrogel, Three-dimensional cell culture
1Bio-industry Unit, Technology Research Laboratory, Shimadzu Corporation., Kyoto Japan
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