Shimadzu Review Vol.76[1・2](2019)


Development of Drug Testing by Direct Analysis of Equine Hair Using Imaging
Mass Microscopy with iMScope TRIO™

by Shuichi Shimma, Ph.D.1Mararu Sese2and Takushi Yamamoto3

Shimadzu Review 76[1・2] (2019.8)


Ingested drugs are known to accumulate in body hair, and the rate of hair growth is, to some extent, determined depending on animals. Along with urine, hair is currently attracting attention as a drug sample in the field of forensics because determination of the locations of a drug in the body hair can provide clues as to when the drug was taken. Mass spectrometry imaging (MSI), which visualizes the localization of compounds in vivo, is attracting attention as a new method for hair analysis. Imaging mass microscope iMScope TRIO is used in various fields because of its capability for MSI in a microscopic area, and has a potential for expanding applications.
In this article, we present an example of drug intake history in the mane of a racehorse administered with dexamethasone phosphate, which was visualized by MSI using iMScope TRIO.

Keywords: Mass Spectrometry Imaging, Imaging mass microscopy, Equine hair, dexamethasone phosphate

1Graduate School of Engineering, Osaka University, Osaka, Japan
2Equine Racing Co., Ltd, Hokkaido, Japan
3Global Application Development Center, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan

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