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Shimadzu Review 77[1・2] (2020.7)
Abstract
Shimadzu has developed the MALDImini-1 matrix-assisted laser desorption/ionization digital ion trap mass spectrome-ter, the smallest MALDI-based mass spectrometer in the world. With a footprint equivalent to an A3 sheet of paper, the unprecedented small size was achieved using Shimadzu’s proprietary digital ion trap (DIT) technology and a new smaller ion optical system. The built-in vacuum pump and standard 100 V AC power supply minimize the laboratory bench space required by the system, so that samples can be measured at the same location where they are prepared.
The DIT technology that contributed to reducing the system size is also especially useful for predicting the structures of unknown compounds (such as protein digestion products, peptides, post-translationally modified peptides, and glycans) by MS/MS or MS3 analysis. MS3 analysis can be used to predict protein digestion products and peptides that cannot be adequately predicted by MS/MS analysis or to analyze more detailed structures of post-translationally modified proteins that cannot be adequately identified with MS/MS measurements. Given the current interest in technology for analyzing data from substances related to glycans by those involved in biopharmaceutical development, for example, the MALDImini-1 is presumably ideal for such applications.
1Koichi Tanaka Mass Spectrometry Research Laboratory, Shimadzu Corporation, Kyoto, Japan
2Life Science Business Department, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan
3MS Business Unit, Life Science Business Department, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan
4Global Application Development Center, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan
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