Shimadzu Review Vol.78[1・2](2021)
Industrial Machinery


Development of On-Line TOC Analyzer for Pure Water

by Tatsuya Kataoka1Masahito Yahata1Mayu Mitsukawa1Yuki Yamauchi2Nobuhiro Namikawa1Yuichi Masuda1

Shimadzu Review 78[1・2] (2021)


TOC measurement in pure water at the μg/L scale is in increasing demand due to stringent quality controls for pharmaceuticals and sophisticated in-process cleaning for semiconductors. Recently, on-line TOC analyzers suitable for continuous monitoring of operations in a pure water production process that pose minimal risk of contamination during sampling are of particular interest. Shimadzu’s eTOC is the world’s smallest and lightest on-line TOC analyzer for pure water. The eTOC uses a mercury -free excimer lamp and is designed with maintenance and utility as a priority, having a calibrator and premade standard solutions. The eTOC also offers high levels of security with user authentication and operational logs. This article presents the results from TOC measurements taken using the eTOC at several tens of μg/L in a plant producing pure water for pharmaceuticals and at 1 μg/L in an ultra pure water production plant, along with the results of system suitability testing using the United States Pharmacopoeia <643> method.

1Environmental Business Unit, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan
2Quality Assurance Department, Analytical & Measuring Instruments Division, Shimadzu Corporation, Kyoto, Japan

*The information contained in Shimadzu Review has not been modified since the original publication date. Please be aware that in some cases, products mentioned within the articles are no longer available.