High throughput quantitation for therapeutic drug monitoring with Open access LC/MS/MS system

In this paper, we introduce four research use only LC/MS/MS methods for therapeutic drug monitoring (TDM), mycophenolic acid, sunitinib and axitinib, voriconazole, itraconazole. TDM is indispensable for managing drug dosage based on the drug concentration in blood in order to conduct a rational and efficient drug therapy. Liquid chromatography coupled with tandem quadrupole mass spectrometry (LC/MS/MS) is increasingly used in TDM because it can perform selective and sensitive analysis by simple sample pretreatment. In the field of TDM, it is necessary to measure the specimen such as plasma or serum quickly after suitable pretreatment and report the precise result. LC/MS/MS system with a simple and user-friendly interface can provide a streamlined workflow and reduce the load of analysts. We developed high-throughput LC/MS/MS methods for TDM with a new data acquisition and processing software.