A Simplified Expedited Screening of Haemoglobinopathy and Pre-Diabetes in Whole Blood Using MALDI MS
- Clinical MALDI-TOF-MS requires not only accurate mass determination but also quantitative measurement e.g. as used in the direct identification of haemoglobinopathy and diabetes from blood prick sample. This has been demonstrated by us and Dr Marvin Vestal's group (1,2,3).
- Two aspects are known to affect the reliability of quantification result in MALDI: (i) number of shots averaged and (ii) optimal dilution of the sample.
- Here, we examine the effect of the acquisition strategy (number of laser shots, sampling method) for achieving optimised but rapid data for qualitative and quantitative blood globin analysis from pin prick blood.
*Not available in the U.S.
- Content Type:
- Paper
- Document Number:
- PO-CON1761E
- Product Type:
- Mass Spectrometry, Life Science Lab Instruments, MALDI-TOF Mass Spectrometry
- Keywords:
- Clinical research, Forensics, Healthcare, Clinical research, MALDI-8020
- Language:
- English
- File Name:
- ego317086.pdf
- File Size:
- 489kb
