Impurity Analysis Using the SPD-M30A Photodiode Array Detector and High-Sensitivity Flowcell

When conducting impurity analysis of pharmaceuticals, researchers need to detect trace level impurities along with the main ingredient, which is present at a high concentration. To accomplish this, a detector that provides linearity over a wide concentration range is required. Furthermore, a high S/N (signal-to-noise ratio) is also required of the detector in order to provide high-accuracy quantitation of any impurities present at trace levels.
Here, we introduce our evaluation of the sensitivity and linearity obtained in impurity analysis using the new SPD-M30A photodiode array detector with the optional high-sensitivity cell (optical path length 85 mm).