Ion Analysis in Drugs (Part 4) Determination of Counterions (Anions) by Ion Chromatography
A variety of counterions are used to selecting the optimum salts in the development stage of a pharmaceutical product because the physicochemical and pharmacokinetic properties associated with the active pharmaceutical ingredients (API) will vary depending on differences in counterions. Furthermore, as inorganic substances such as catalysts and ions used during synthetic process may affect such properties as solubility and stability, it is very important to conduct analysis of ionic contaminants. In order to eliminate the impurities from the synthesized API, HPLC is commonly used for fractionation and preparative purification.
Here, we introduce some examples of the analysis of acetate, formate, chloride, and trifluoroacetate ions in a pharmaceutical product.
- Content Type:
- Application
- Document Number:
- LAAN-A-LC-E234
- Product Type:
- Liquid Chromatography
- Keywords:
- IC, Ion chromatography, Anions, Pharmaceutical analysis, Pharmaceutical, Life Science, Development (Formulation, Scale-up, Method development), Shim-pack IC-A3
- Language:
- English
- File Name:
- jpl214019.pdf
- File Size:
- 961kb