USP-Compliant Analysis of Vitamin in Dietary Supplement: Analysis of Cyanocobalamin by Nexera™ XR

Vitamin B12 is involved in blood formation and metabolism, but it cannot be synthesized in the body and is rarely found in foods of plant origin. Most of commercially available dietary supplements contain vitamin B12 due to the tendency that the aged persons and vegetarians are susceptible to the deficiency of vitamin B12. Generally, the amount of vitamin B12 is expressed as the cyanocobalamin equivalent value.
Here, a USP40-NF35-compliant system suitability test for cyanocobalamin, representing vitamin B12, was conducted using a Shimadzu Nexera™ XR. The compatibility of Nexera XR and Prominence™ was also verified. This article introduces an analysis of a multivitamin tablet.