Improvement of Peak Shape in Analysis of Basic Compounds and Reduction of Carryover by Multi-Rinse Function

In analysis of basic compounds, tailing or other deterioration of the peak shape is sometimes observed. A good peak shape can be obtained in analyses of basic compounds by using the Shim-pack Arata C18 column, even in analyses with a simple mobile phase. Chlorhexidine is a compound that adsorbs extremely easily on the wetted parts of autosamplers. The Nexera™ X3 system is equipped with multi-rinse function as a standard to reduce carryover by automatically rinsing the injection port, where carryover frequently occurs.
This article introduces an analysis of basic compounds utilizing a combination of Nexera X3 and Shim-pack Arata C18, together with carryover reduction by multi-rinse function.