Analysis of Impurities in Pharmaceutical Ingredients Using Trap-Free Two-Dimensional HPLC and Triple Quadrupole LC/MS/MS (LCMS-8040)

Controlling and confirming trace impurities contained in products in terms of the type, quantity, and safety has become an increasingly important issue to guarantee the product quality in a wide range of fields, including drugs, foods and fine chemical products.
Here, we introduce an example of analysis in which trap-free two-dimensional HPLC was used to detect impurities using non-volatile mobile phase conditions, which were then converted without complication to volatile mobile phase conditions online to complete the analysis using the LCMS-8040 triple quadrupole mass spectrometer.