Development of online SFE-LC/MS system for analysis of metabolites in microbial cells
In bio-based fine chemical production, a short breeding cycle time of microbes is a key issue for improving productivity. Metabolomics has been widely used as a quick and comprehensive analytical procedure due to its excellent features of dynamic monitoring and quick evaluation for bio-production. On the other hand, sample pretreatment procedure is still generally tedious and time consuming while high-throughput analytical methods using LC/MS and GC/MS. We present the development of online SFE-LC/MS system that provides completely automated analytical process resulting labor-saving.
- Content Type:
- Paper
- Document Number:
- PO-CON1796E
- Product Type:
- Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
- Keywords:
- Nexera UC SFE system, LCMS-8060 triple quadrupole mass spectrometer, metabolite, microbial cells, Pharmaceutical, Life Science, Metabolomics, online SFE-LC/MS system
- Language:
- English
- File Name:
- jpo118024.pdf
- File Size:
- 728kb