Analysis of Perfluorinated Alkyl Acids Specified in EPA M537 and Beyond Using LCMS-8045

There has been an increasing awareness of the presence of perfluoroalkyl sulfonates (PFOS) and perfluoroalkyl carboxylic acids (PFCAs) in water. Although perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the most studied polyfluoroalkyl substances (PFASs), perfluoroalkyl and polyfluoroalkyl substances with chain lengths varying from C2-C14 have also been detected in various sample matrices. The continued use of these compounds presents a long-term challenge to scientist, industry leaders, and public health officials worldwide. This presentation describes a highly sensitive Solid Phase Extraction (SPE) - Liquid Chromatography - Tandem Mass Spectrometry (LC-MS/MS) Method for the determination of twenty-four specific polyfluorinated chemical (PFCs), fourteen of which are listed in EPA M537 in drinking waters.