A metabolomics study into influenza virus infection by HRAM Q-TOF analysis

Animal models help to understand mechanisms of virulence and to develop more efficacious vaccines and forms of prevention or treatment. Influenza virus infection in humans has a number of similarities with that in swine as the clinical manifestation and pathogenesis are similar. In this untargeted metabolomics study, HRAM Q-TOF analysis was used to measure the effect of influenza virus infection on host-microbial metabolism in swine and whether this differs between the early, innate response, the later adaptive response and the repair phase. Blood samples taken pre-infection and over 13 days post infection (dpi) were compared.

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Liquid Chromatograph-Mass Spectrometry, Mass Spectrometry
Q-TOF, influenza virus infection, Clinical research, Forensics, Pharmaceutical, Life Science, DMPK, ADME, Safety testing, Metabolomics, Clinical research, LCMS-9030
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