A metabolomics study into influenza virus infection by HRAM Q-TOF analysis

Animal models help to understand mechanisms of virulence and to develop more efficacious vaccines and forms of prevention or treatment. Influenza virus infection in humans has a number of similarities with that in swine as the clinical manifestation and pathogenesis are similar. In this untargeted metabolomics study, HRAM Q-TOF analysis was used to measure the effect of influenza virus infection on host-microbial metabolism in swine and whether this differs between the early, innate response, the later adaptive response and the repair phase. Blood samples taken pre-infection and over 13 days post infection (dpi) were compared.