Analysis of Residual Solvents in Pharmaceuticals Using a He Alternative Carrier Gas

The United States Pharmacopeia (USP) General Chapter <467> on Residual Solvents provides test methods for residual solvents in pharmaceuticals, mainly using headspace gas chromatography (GC).
Helium (He) is generally used as the carrier gas, but analysis using an alternative carrier gas such as N2 or H2 has also been in demand, as He shortages and soaring prices have become an issue in recent years.
The following applications introduce a pharmacopeia-compliant analysis of Class 1 and 2 residual solvents using an alternative carrier gas..

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