Chapter 1 Introduction to LCMS

Liquid Chromatograph-Mass Spectrometry

Introduction to LCMS

The first chapter of Shimadzu's Fundamental Guide to LCMS introduces the basic principles of LC and MS. Common LC techniques, namely reversed-phase, normal phase and size exclusion chromatography, are described. Next, we introduced LCMS and compared it with other ionization and analytical techniques. Due to its superior sensitivity, high mass accuracy and robust performance, LCMS plays a key role and is widely used in many industries such as clinical, biopharmaceuticals, food safety and environmental.