May 29, 2024 | News & Notices Providing More Reliable Data with High Sensitivity and Stability, and Heightening the Efficiency of Laboratory Work with Automatic Calibration
Release of the LCMS-TQ RX Series High-Performance Liquid Chromatograph Mass Spectrometers

Top: LCMS-8060RX Triple Quadrupole High-Performance Liquid Chromatograph Mass Spectrometer Bottom from the Left: LCMS-8050RX and LCMS-8045RX

Top: LCMS-8060RX Triple Quadrupole High-Performance Liquid Chromatograph Mass Spectrometer
Bottom from the Left: LCMS-8050RX and LCMS-8045RX

Shimadzu Corporation released the LCMS-8060RX, LCMS-8050RX, and LCMS-8045RX triple quadrupole high-performance liquid chromatograph mass spectrometers globally. The three models in the LCMS-TQ RX series carry onward the basic functionality of Shimadzu triple quadrupole (TQ) liquid chromatograph mass spectrometers (LC-MS), while providing even higher sensitivity, stability, and convenient operability. Shimadzu is releasing this series for manufacturers and contract analysis organizations in the pharmaceutical, environmental, and food product sectors.

In the pharmaceutical, environmental, and food product sectors, regulations have become stricter, and there is an increasing demand to obtain reliable data with highly stable instruments. In particular, the global market for TQ LC-MS instruments with their high sensitivity and selectivity is expected to grow by at least 8 % annually, and the objectives and sectors where they are applied have diversified. In routine analysis applications, which account for 40 % of the TQ LC-MS market, a number of samples are measured consecutively, so data reliability and shortened downtime are important. In addition to basic performance, such instruments must provide both stability and operability.

With the LCMS-TQ RX series, the data reliability has been heightened by stabling the sample ionization with the ion source improved. This series is equipped with functions that check the instrument status prior to measurements, and automatically implement calibration (tuning), as well as ecology mode for minimizing standby power consumption, thereby achieving high-efficiency laboratory operations with a low environmental impact. Through this series, Shimadzu will heighten the efficiency of laboratory work related to pharmaceuticals, food product development, and environmental inspection so that we contribute to the growth of research and development in healthcare, green transformation, and other sectors.


1. Improving Data Reliability with High Stability and Measurement Sensitivity

In the LCMS-TQ RX series, the ion source is equipped with the newly developed CoreSpray nozzle. The stability of the analysis data has been increased by uniformizing the sample spray with improving the shape of the nozzle used to nebulize the sample. In the past, only some models were equipped with IonFocus*, starting with this series all models are now equipped with the function as standard. Higher measurement sensitivity and robustness have been achieved by more efficiently injecting only the ions into the mass spectrometer.

2. Maintaining Favorable Instrument Conditions, Heightening the Efficiency of Laboratory Operations

The Performance Concierge function checks the mass accuracy, spectral intensity and other instrument conditions before starting measurements, and automatically implements tuning depending on the results. Consistently maintaining the instrument in optimal condition controls the tuning times and reduces downtime.

3. Minimization of Power Consumption by the Instrument itself, and Reducing Load on the Lab and the Environment

In ecology mode, the instrument monitors its own usage, and if it has not been used for a set period of time, it automatically shuts down. Conventionally, the inside of the instrument continues to be heated even after measurements are finished. By minimizing this, power consumption is reduced by approximately 31 %.

  • *This proprietary Shimadzu ion source provides high sensitivity and durability by eliminating contaminant components. It does so through the efficient intake of ions to the mass spectrometer utilizing the techniques of fluid and electric field analysis. Conventionally, only the LCMS-8060NX was equipped with this.

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