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LCMS-8065XE Triple Quadrupole High-Performance Liquid Chromatograph Mass Spectrometer

On August 7, Shimadzu Corporation will release the LCMS-8065XE triple quadrupole high-performance liquid chromatograph mass spectrometer in Japan and abroad. This product inherits the basic functionality of our triple quadrupole (TQ) liquid chromatograph mass spectrometers (LCMS) while further improving sensitivity and robustness. Shimadzu is marketing this product primarily for PFAS analysis, aiming to cultivate the PFAS market, which is experiencing rapid growth in demand.

PFAS (per- and polyfluoroalkyl substances) are widely used in everything from wrapping paper and other daily necessities to semiconductors and other industrial products because of their water repellency, thermostability, and grease-proof properties. At the same time, PFAS are known as “forever chemicals” that do not degrade in the natural environment. They remain in the soil and in water sources, impacting water quality and ecosystems. Among the over 10,000 different PFAS substances, PFOS and PFOA in particular have drawn international attention because they heighten health risks, including the threat of cancer and endocrine disruption. In the United States, various states have implemented strict regulations, and in the EU, regulations on standard values are expected to be strengthened by 2026. The permitted standards for PFAS in drinking water are particularly strict, and detection limit reductions down to the ppt (1 part in a trillion) level are required. This has heightened demand for analytical instruments capable of high-performance multicomponent simultaneous analysis in the PFAS analysis market, which is expanding year by year.

The LCMS-8065XE is based on UF Technologies, Shimadzu’s proprietary ultra-fast measurement technology, with improvements to the ion source and optimization of the detector, resulting in greatly improved sensitivity performance. It provides all-in-one solutions combining PFAS analysis methods and data analysis software. Its latest user support technology also reduces laboratory and environmental load. With this product, Shimadzu is addressing the need for high-sensitivity PFAS analysis in the healthcare and green domains, which are considered sectors of social value creation.

Features

1. Newly Developed Technology Significantly Improves Analysis Performance

In addition to IonFocus functionality*1, which was included in previous models, the newly designed StreamFocus has been adopted for the ESI ion source in this product. By narrowing the diameter of the sample discharge nozzle, the spread of the spray is controlled, heightening the efficiency of the intake of ions into the mass spectrometer. Further, by introducing a new collision cell*2 with an enlarged inlet lens diameter and multiple lenses added, the amount of ions transmitted has been increased, heightening sensitivity.

• *1: Through the efficient intake of ions into the mass spectrometer using fluid analysis and electric field analysis techniques, Shimadzu’s proprietary ion source eliminates contaminants, thereby providing high sensitivity and robustness.
• *2: A device for colliding ions in the process of mass spectrometry to cause further decomposition or to obtain specific information.

2. Providing the All-in-One Solutions Required for PFAS Analysis

Shimadzu’s broad lineup of products includes not only LCMS, but also analysis methods, data analysis software, and columns, vials, and other consumables. The all-in-one FluoroSuite is created in response to the PFAS analysis needs of the respective customers.

3. The Latest User Support Technology Improves the Operational Efficiency of Laboratories

The Performance Concierge AI function automatically diagnoses the instrument status, supporting analysis under the optimal conditions. Additionally, Ecology Mode, in which the instrument itself monitors usage status and automatically shuts down when appropriate, is built in, leading to power savings of about 30 % over previous models.

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LCMS-8065XE Triple Quadrupole High-Performance Liquid Chromatograph Mass Spectrometer