Characteristic Analysis & Quality Control
Nucleic acid therapeutics have recently attracted particular attention as a new pharmaceutical modality. Unlike biopharmaceuticals, nucleic acid therapeutics can be produced by cost-effective chemical synthesis. The development and standardization of analytical methods for quality control are still in progress, with efforts being made in collaboration with industry and academia. In the development and evaluation of nucleic acid therapeutics, it is essential to understand their thermal stability, as this is a factor that controls their structure and functions. The confirmation whether or not synthesized nucleic acid therapeutics are arranged in the intended base sequence is also a critical quality characteristic to ensure the action of pharmaceuticals.