Trap-Free 2D LC/MS system for Quadrupole LCMS
Enhancing the Efficiency of Impurity Analysis
When impurities are detected by UV under non-volatile mobile phase conditions, does one need to adapt the method to use volatile mobile phase additives for LCMS confirmation?
With the use of a Trap-free 2D LCMS system, no additional method development is required because mobile phases can be changed online.
- Online switching between a non-volatile mobile phase and a volatile mobile phase
- Convenient support tool coordinated within LabSolutions
- Only the impurities of interest are introduced to the MS system, so there are no concerns about peak misalignment.
Creating a Time Program and Batch Schedule using the Support Tool
The optimal valve sequence can be constructed by entering the retention times for impurity peaks observed in the first-dimension UV chromatogram, and then a batch schedule can be created to acquire data on multiple impurities and their respective blanks.
Using the Data Browser Makes Identification of Impurities Easy
Remarks and Precautions
- The Trap-Free 2D LCMS System is a application system and is configured with LC units, Quadrupole mass spectrometer, and start kit
News / Events
Shimadzu has released the LCMS-9050 Quadrupole Time-of-Flight Liquid Chromatograph Mass Spectrometer.
The LCMS-9050 is a quadrupole Time-of-Flight (Q-TOF) mass spectrometer system designed with technologies developed for Shimadzu LCMS series models and that results in among the highest mass accuracy stability levels available.
Dementia / Alzheimer‘s disease
Shimadzu is a leading driver in developing healthcare solutions with technology developments ranging from advanced imaging systems for use in medical diagnosis and treatment, engineering mass spectrometry-based solutions for exploring ways to discover disease biomarkers as well as building MS solutions for daily routine quantitation in biological fluids.
Anti-doping policies, rules and regulations are governed by the World Anti-Doping Agency (WADA). Doping is not only harmful to athletes who take performance-boosting drugs, but also affects the integrity of a sport. Shimadzu instruments can help ensure clean sports and here are a few applications.
Shimadzu has released the LCMS-2050 High-Performance Liquid Chromatograph Mass Spectrometer.
The LCMS-2050 single quadrupole mass spectrometer combines the user-friendliness of an LC detector with the excellent performance of MS to provide a complete package of easy to use high-level performance and compactness.
Shimadzu has released High Resolution Accurate Mass Library for Forensic Toxicology
The High Resolution Accurate Mass (HRAM) Library includes two MS/MS spectral libraries. Each library is built using two different separation conditions and is suitable for targeted or non-targeted screening of drugs of abuse, psychotropic drugs, pharmaceuticals, pesticides, and other compounds of toxicological interest.
What is a Method Package?
Method Package contains ready-to-use analytical conditions and sample pretreatment procedures optimized for Shimadzu mass spectrometers and specific analytical applications.