Technical Report: "Total Solution for Metabolomic Analysis of Endogenous Metabolites Using Exact Mass Database"
Trap-Free 2D LC/MS system for Quadrupole LCMS
Enhancing the Efficiency of Impurity Analysis
When impurities are detected by UV under non-volatile mobile phase conditions, does one need to adapt the method to use volatile mobile phase additives for LCMS confirmation?
With the use of a Trap-free 2D LCMS system, no additional method development is required because mobile phases can be changed online.
- Online switching between a non-volatile mobile phase and a volatile mobile phase
- Convenient support tool coordinated within LabSolutions
- Only the impurities of interest are introduced to the MS system, so there are no concerns about peak misalignment.
Creating a Time Program and Batch Schedule using the Support Tool
The optimal valve sequence can be constructed by entering the retention times for impurity peaks observed in the first-dimension UV chromatogram, and then a batch schedule can be created to acquire data on multiple impurities and their respective blanks.
Using the Data Browser Makes Identification of Impurities Easy
Remarks and Precautions
- The Trap-Free 2D LCMS System is a application system and is configured with LC units, Quadrupole mass spectrometer, and start kit
News / Events
Shimadzu has released the LC/MS/MS Method Package for Short Chain Fatty Acids
Shimadzu has released the LC/MS/MS Method Package for Lipid Mediators Ver. 3
Shimadzu has released the LC/MS/MS Method Package for Veterinary Drugs Ver. 2
Shimadzu has released the LC/MS/MS Method Package for Bile Acids Ver. 2.
User interviews December 2020
Our field of activity is contract research and testing for life sciences industries including pharma, biotech, nutraceuticals, environmental sciences, food&agri testing, and diagnostics.